2021 Tenerife Ladies Open

The 2021 Tenerife Ladies Open was a women's tennis tournament played on outdoor hard courts. It was the first edition of the Tenerife Ladies Open, and part of the WTA 250 series of the 2021 WTA Tour. It was held at the Abama Tennis Academy in Guía de Isora, Spain, from 18 until 24 October 2021.

• Ann Li def. Camila Osorio 6–1, 6–4

This is Li's first career WTA title.

• Ulrikke Eikeri / Ellen Perez def. Lyudmyla Kichenok / Marta Kostyuk, 6–3, 6–3

• Rankings are as of October 4, 2021.

The following players received wildcards into the main draw:

• Rebeka Masarova
• Nuria Párrizas Díaz
• Lucrezia Stefanini

The following player received entry using a protected ranking:

• Zheng Saisai

The following players received entry from the qualifying draw:

• Aliona Bolsova
• Jaqueline Cristian
• Mandy Minella
• Donna Vekić
• Stefanie Vögele
• Wang Xinyu

The following player received entry as a lucky loser:

• Kaja Juvan

Before the tournament

• Caroline Garcia → replaced by Arantxa Rus
• Magda Linette → replaced by Greet Minnen
• Jasmine Paolini → replaced by Danka Kovinić
• Rebecca Peterson → replaced by Kaja Juvan
• Martina Trevisan → replaced by Varvara Gracheva

• Rankings are as of October 4, 2021.

The following pairs received wildcards into the doubles main draw:

• Paula Arias Manjón / Sara Sorribes Tormo
• Cristiana Ferrando / Lucrezia Stefanini

The following pair received entry using a protected ranking:

• Beatrice Gumulya / Peangtarn Plipuech

Before the tournament

• Kirsten Flipkens / Hsieh Su-wei → replaced by Emina Bektas / Tara Moore

• Vivian Heisen / Kimberley Zimmermann → replaced by Vivian Heisen / Andreea Mitu

• Greet Minnen / Alison Van Uytvanck → replaced by Beatrice Gumulya / Peangtarn Plipuech

• Andreea Mitu / Lesley Pattinama Kerkhove → replaced by Anna Bondár / Dalma Gálfi

• Official website

• WTA Official website