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2-Fluoromethcathinone
2-Fluoromethcathinone (2-FMC), also known as 2-flephedrone, is a psychostimulant and designer drug of the cathinone family. It acts as a dopamine and norepinephrine releasing agent (NDRA).
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| 2-FMC; 2-Fluoromethylcathinone; 2-Fluoro-N-methylcathinone; 2-Flephedrone |
| Stimulant; Norepinephrine–dopamine releasing agent |
| IUPAC name |
| 1-(2-fluorophenyl)-2-(methylamino)propan-1-one |
| .mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}1186137-35-8 |
| 71316821 |
| 37701826 |
| 7NLX9J64KY |
| DTXSID401017070 |
| C10H12FNO |
| 181.210 g·mol−1 |
| Interactive image |
| SMILES |
| CC(C(=O)C1=CC=CC=C1F)NC |
| InChI |
| InChI=1S/C10H12FNO/c1-7(12-2)10(13)8-5-3-4-6-9(8)11/h3-7,12H,1-2H3Key:DCMOUMKIDLRIBO-UHFFFAOYSA-N |
2-Fluoromethcathinone (2-FMC), also known as 2-flephedrone, is a psychostimulant and designer drug of the cathinone family. It acts as a dopamine and norepinephrine releasing agent (NDRA).
The drug has an EC50Tooltip half-maximal effective concentration for dopamine release of 48.7 nM and induces 85% release of norepinephrine at a concentration of 10 μM. For comparison, the EC50 values of methcathinone are 49.9 nM for dopamine release and 22.4 nM for norepinephrine release and it induces 100% release of norepinephrine at a concentration of 10 μM. Hence, compared to methcathinone, 2-FMC appears to be relatively more selective or efficacious for induction of dopamine release over norepinephrine release. It is notable in this regard that selective dopamine releasing agents are largely unknown.
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3-Fluoromethcathinone
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4-Fluoromethcathinone (flephedrone)
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2-Fluoromethamphetamine
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2-FMC (2-Fluoromethcathinone) - Isomer Design
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