From Surf Wiki (app.surf) — the open knowledge base

1H-LSD

Column 1


1-Hexanoyl-LSD; SYN-L-027
.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}
DE: NpSG (Industrial and scientific use only)
UK: Under Psychoactive Substances Act
US: Unscheduled (may be covered by the Federal Analogue Act if sold for human consumption)
UN: Unscheduled
IUPAC name
(6aR,9R)-N,N-diethyl-6-methyl-4-hexanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
170763690
C26H35N3O2
421.585 g·mol−1
Interactive image
SMILES
CN1CC(C=C2[C@H]1Cc1cn(C(=O)CCCCC)c3cccc2c31)C(=O)N(CC)CC
InChI
InChI=1S/C26H35N3O2/c1-5-8-9-13-24(30)29-17-18-15-23-21(20-11-10-12-22(29)25(18)20)14-19(16-27(23)4)26(31)28(6-2)7-3/h10-12,14,17,19,23H,5-9,13,15-16H2,1-4H3/t19?,23-/m1/s1Key:RSBBZALMPUUEKF-LEQGEALCSA-N

1H-LSD, also known as 1-hexanoyl-LSD or as SYN-L-027, is an acylated derivative of lysergic acid diethylamide (LSD), with a six carbon hexanoyl chain attached to the N1 position. It acts as a prodrug for LSD, and in animal studies produces drug-appropriate responding with a similar potency to short-chain homologues such as ALD-52 and 1P-LSD, in contrast to the 4 and 5 carbon homologues 1B-LSD and 1V-LSD which are several times weaker.

1H-LSD produces similar effects to LSD with a shorter metabolic half-life. There are no documented cases of it being used recreationally.

Analogues of 1H-LSD include ALD-52 (1A-LSD), 1P-LSD, 1cP-LSD, 1DD-LSD, 1cP-AL-LAD, and 1P-ETH-LAD, among others.

1H-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025.

1H-LSD is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

Substituted lysergamide
Lizard Labs
1H-LSD - Isomer Design

Want to explore this topic further?

Ask Mako anything about 1H-LSD — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report